One of the things I once used to great effect in a game I ran was the idea of 'Seasons'. Like TV shows here in America, I'd try to break my campaign/chronicle down to a limited amount of adventures. I'd try to ahead of time decide the number of adventures- or episodes for the sake of analogy. I considered it a great creative boon for writing long plots. If you know its going to only last ten adventures, then you can go ahead and try foreshadowing in adventures two and three.
The other advantage of the use of Seasons is that it allowed me to End the Campaign on a note. I always approached the end of a Season with a finale- meant to cut off the campaign and end it nicely. When I've run games that didn't use the Seasons idea, they kinda just lingered and died. The story was still there, but it had faded away, and never really was resolved like it could be. Unfortunately, this style sometimes can conflict with the idea of a the super-long serial type game.
As for Equinox, I think its 'Season' might consist of 15 episodes. The goal being to reach a stellar conclusion at the end of 15 episodes will be a great goal. Hopefully by then I'll have obtained the inspiration for another game.